Ameliorate role of alpha lipoic acid on the beta amyloid accumulation and some serum oxidant / antioxidants levels in brain aging induced by d-gal in male rats

Alpha lipoic acid has both hydrophilic and hydrophobic properties is widely dispersed in cellular membranes the cytoplasm. It one of most powerful antioxidants for cells. The current research looked at possible therapeutic benefits alpha acid) a male rat model D-galactose-induced brain aging. G1 normal as control group, G2 animals were given 200 mg/kg bw.IP. daily D-gal group 30 days, G3 100 mg/kg. G4 + group200mg/kg with IP every day days.The accumulation Beta amyloid changes serum oxidant/antioxidant levels Increased oxidative stress indicators our data demonstrate that aging causes an increase deposition, well substantial rise MDA, GSH, CAT, SOD levels. To summarize, focused on damage caused by D-gal, which can be mitigated intubating B.W.IP. ALA to counteract its negative effects.